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What is it?

Cryo-electron tomography is an imaging method similar to cryo-electron microscopy. However, the primary difference between the two lies in that cryoEM relies on hundreds of thousands of different particles to composite into a single 3-D model, and cryoET uses a single particle, but hundreds of images.

The advantage of cryoET over cryoEM is that structures that are flexible or otherwise specific to a single particle can be rendered. The disadvantage is that because one must put the same particle under radiation for the entire duration of imaging, the number of images that can be taken is limited.